McMaster University

Michael G. DeGroote
National Pain Centre

Scope of Search

Canadian Guideline for Safe and Effective Use of Opioids for Chronic Non-Cancer Pain

Appendix B-8: Opioid Conversion and Brand Availability in Canada

  • Oral Opioid Analgesic Conversion Table
  • Opioids: Generic and Brand Names Available in Canada

Appendix B-8.1 Oral Opioid Analgesic Conversion Table

  • The table is based on oral dosing for chronic non-cancer pain.
  • The figures are based on the Compendium of Pharmaceutical & Specialties (Canadian Pharmacists Association 2008) and a systematic review by Pereira (2001). Wide ranges have been reported in the literature.
  • These equivalences refer to analgesic strength of oral opioids, and not psychoactive effects or effectiveness in relieving withdrawal symptoms.
  1. Equivalence to oral morphine 30 mg:
  2. Table B Appendix 8.1 Oral Opioid Analgesic Conversion Table

      Equivalence to oral morphine 30 mg: To convert to oral morphine equivalent, multiply by: To convert from oralmorphine, multiply by:
    Morphine 30 mg 1 1
    Codeine 200 mg 0.15 6.67
    Oxycodone 20 mg 1.5 0.667
    Hydromorphone 6 mg 5 0.2
    Meperidine 300 mg 0.1 10
    Methadone and tramadol Morphine dose equivalence not reliably established.
  3. Equivalence between oral morphine and transdermal fentanyl:
  4. Transdermal fentanyl* 60–134 mg morphine = 25mcg/h
    135–179 mg = 37 mcg/h
    180–224 mg = 50 mcg/h
    225–269 mg = 62 mcg/h
    270–314 mg = 75 mcg/h
    315–359 mg = 87 mcg/h
    360–404 mg = 100 mcg/h

    * Formulations include 12, 25, 50, 75 and 100 ucg/hour patches, but the 12 ucg/hour patch is generally used for dose adjustment rather than initiation of fentanyl treatment.

Appendix B-8.2 Opioids: Generic and Brand Names Available in Canada

(Canadian Pharmacists Association 2008)

Strong Opioids

Drug (generic name) Brand names
Fentanyl (transdermal) Duragesic®
Hydromorphone HCL Dilaudid®, Hydromorph Contin®, Hydromorphone HCL, Hydromorphone HP® (10, 20, 50, Forte), Jurnista®, PMS-Hydromorphone®
Methadone HCL Metadol®
Morphine sulfate Statex®, Kadian®, M-Eslon®, M.O.S.-Sulfate®, Morphine HP, Morphine sulphate, MS Contin®, MS-IR®, PMS-Morphine®, Morphine Sulfate SR®, ratio-Morphine SR®
Oxycodone HCL OxyContin®, Oxy-IR®, Supeudol®
Oxycodone HCL with acetaminophen Endocet®, Percocet®, Percocet-Demi®, ratio-Oxycocet®, PMS- Oxycodone- Acetaminophen®
Oxycodone HCL/ ASA Endodan®, Percodan®, Percodan-Demi®, ratio-Oxycodan®

Weak Opioids

Drug (generic name) Brand names
Codeine monohydrate/ sulphate trihydrate Codeine, Codeine Contin®
Codeine phosphate / acetaminophen / caffeine Tylenol® (No. 1, 2, 3); Atasol® (No. 8, 15, 30); Lenoltec®
Codeine phosphate / acetaminophen without caffeine Empracet®
Propoxyphene Napsylate Darvon-N®
Pentazocine HCL *Talwin®
Pethidine HCL (meperidine) Demerol®
**Tramadol Ralivia™, Zytram XL®, Tridural™
**Tramadol/ Acetaminophen Tramacet®


Drug (generic name) Brand names
Nabilone Cesamet®
Dronabinol Marinol®

* Opioid agonist/antagonist

** Tramadol is a weak opioid and serotonin/norepinephrine reuptake inhibitor

*** Orobuccal spray containing extracts of natural cannabis

Note: Reference throughout this document to specific pharmaceutical products as examples does not imply endorsement of any of these products.